If you expect the best of the best, enjoy outstanding service and experience luxury like no other in Main Street Hyannis 4-star properties. These hotels and Resorts feature luxury and signature rooms as well as spacious king suites, Deluxe rooms with king bed or two queen beds. Find the best Hotel deals and unwind in style at iconic four star hotels in Main Street Hyannis. These world class Main Street Hyannis hotels offer luxurious accommodations with premium locations. Check out this list of Main Street Hyannis ultra-luxury hotels to pamper yourself. From modern to classic the Main Street Hyannis area hotels offer something for your specific requirements and taste.